FlyWire — Drosophila brain connectome (~139k neurons) 3D

The first complete connectome of an adult Drosophila melanogaster brain (Dorkenwald, Schlegel et al. 2024) — ~139,000 proofread neurons and ~50 million synapses, reconstructed from the FAFB whole-brain serial-section electron-microscopy volume. This scene is the WHOLE brain: all 139,244 neurons with a numeric root_id in the Schlegel et al. 2024 annotation set, spanning every super class — optic-lobe intrinsic neurons, central-brain intrinsic neurons, sensory and ascending/descending pathways, and the visual projection/centrifugal systems. Each neuron is a full surface mesh (meshopt-q14-compressed 3D-Tiles octree) tagged with the whole-brain annotations: super class, cell class, cell type, hemibrain match, information flow, side, predicted neurotransmitter, and hemilineage. Each neuron is colored individually; switch "Color By" to Cell Type, Super Class, Predicted NT, or Side to read the circuit's organization. At 139k neurons the full brain is a dense volume — use the viewer's filter / Force-Zoom coarse LOD to explore subsets and regions.

Metadata

features	139,244 meshes
zoom	0–4
tiles	2,073

Provenance & reproducibility

Source: https://flywire.ai/
License: CC BY-NC 4.0
Cite: Dorkenwald S, et al. Neuronal wiring diagram of an adult brain. Nature 634:124-138 (2024) doi:10.1038/s41586-024-07558-y; Schlegel P, et al. Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature 634:139-152 (2024) doi:10.1038/s41586-024-07686-5; Zheng Z, et al. A complete EM volume of the adult Drosophila brain. Cell 174:730-743 (2018). FlyWire 783 public release, CC BY-NC 4.0.

download_flywire.py --tile --select all --lod 1 --max-zoom 4 --compression meshopt-q14 (139,244 neurons; meshes via cloud-volume from the public flat bucket precomputed://gs://flywire_v141_m783 at multires LOD 1, anonymous/no token; annotations from the token-free flyconnectome/flywire_annotations Supplemental_file1 TSV, keyed by 783 root_id; u16-quantized meshopt GLB 3D-Tiles octree)
muDM: neuron surfaces → TIN tiles; per-neuron color by root_id (hash); tags from the Schlegel et al. 2024 annotations: cell_type, super_class, cell_class, cell_sub_class, hemibrain_type, flow, side, predicted_nt (+conf), hemilineage, supertype, fbbt_id, vfb_id (VirtualFlyBrain cross-ref)

Programmatic access

3D Tiles entry point:

https://ngrf.mudm.io/tiles/flywire/tileset.json

Machine descriptors: tilejson.json · croissant.json · full access guide